p-Fluoronitrobenzene → HCID 23154989, compound

HRID 1912844Notes

Reaction equation

Cl[C:2]1[N:10]=[CH:9][N:8]=[C:7]2[C:3]=1[NH:4][CH:5]=[N:6]2.[N:11]1([CH2:17][CH2:18][NH2:19])[CH2:16][CH2:15][O:14][CH2:13][CH2:12]1.F[C:21]1[CH:26]=[CH:25][C:24]([N+:27]([O-])=O)=[CH:23][CH:22]=1.[Cl:30][C:31]1[CH:36]=[CH:35][C:34]([N:37]=[C:38]=[O:39])=[CH:33][C:32]=1[C:40]([F:43])([F:42])[F:41]>>[Cl:30][C:31]1[CH:36]=[CH:35][C:34]([NH:37][C:38]([NH:27][C:24]2[CH:25]=[CH:26][C:21]([N:6]3[CH:5]=[N:4][C:3]4[C:7]3=[N:8][CH:9]=[N:10][C:2]=4[NH:19][CH2:18][CH2:17][N:11]3[CH2:16][CH2:15][O:14][CH2:13][CH2:12]3)=[CH:22][CH:23]=2)=[O:39])=[CH:33][C:32]=1[C:40]([F:41])([F:42])[F:43]

Participants

Reactant 4

HCID 9590p-Fluoronitrobenzene

HCID 4082852-Morpholinoethylamine

HCID 27332651-Chloro-4-isocyanato-2-(trifluoromethyl) benzene

HCID 53592776-Chloropurine

Product 1

HCID 23154989HCID 23154989, compound

Procedure

The title compound can be synthesized from 6-chloropurine, 2-morpholin-4-ylethylamine, 4-fluoronitrobenzene and 4-chloro-3-(trifluoromethyl)phenyl isocyanate by using the same techniques as in Example 35.

Sources & evidence

ORD record: ord-0e16a149d44b4abf9ad5e3da2fb153aa
Source dataset: uspto-grants-2013_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08609656B2

Reaction notes

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