Dimethylamine → 1-(4-Dimethylaminomethyl-3-(trifluoromethyl)phenyl)-3-[4-(6-(methylamino)purin-9-yl)phenyl]urea
Reaction equation
[CH3:1][NH:2][CH3:3].C(O[C:9](=O)[N:10]([C:12]1[N:20]=[CH:19][N:18]=[C:17]2[C:13]=1[N:14]=[CH:15][N:16]2[C:21]1[CH:26]=[CH:25][C:24]([NH:27][C:28]([NH:30][C:31]2[CH:36]=[CH:35][C:34]([CH:37]=O)=[C:33]([C:39]([F:42])([F:41])[F:40])[CH:32]=2)=[O:29])=[CH:23][CH:22]=1)C)(C)(C)C>>[CH3:1][N:2]([CH2:37][C:34]1[CH:35]=[CH:36][C:31]([NH:30][C:28]([NH:27][C:24]2[CH:25]=[CH:26][C:21]([N:16]3[CH:15]=[N:14][C:13]4[C:17]3=[N:18][CH:19]=[N:20][C:12]=4[NH:10][CH3:9])=[CH:22][CH:23]=2)=[O:29])=[CH:32][C:33]=1[C:39]([F:42])([F:40])[F:41])[CH3:3]Participants
3
Procedure
The title compound can be prepared from dimethylamine and (9-{4-[3-(4-formyl-3-(trifluoromethyl)phenyl)-ureido]phenyl}-9H-purin-6-yl)-methyl-carbamic acid tert-butyl ester by using the same techniques as in Example 168.
Sources & evidence
- ORD record
- ord-8487ea2b6d2744d2afdb39a33ca2db02
- Source dataset
- uspto-grants-2013_12
- Patent number
- US08609656B2
Reaction notes
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