Hydrochloric Acid → HCID 23154947, compound

HRID 1912880Notes

Reaction equation

HRID 1912880 reaction equation
C[O:2][C:3]([C:5]1[N:13]=[CH:12][N:11]=[C:10]2[C:6]=1[N:7]=[CH:8][N:9]2[C:14]1[CH:19]=[CH:18][C:17]([NH:20][C:21]([NH:23][C:24]2[CH:29]=[CH:28][C:27]([Cl:30])=[C:26]([C:31]([F:34])([F:33])[F:32])[CH:25]=2)=[O:22])=[CH:16][CH:15]=1)=[O:4].[OH-].[Na+].Cl>CO>[Cl:30][C:27]1[CH:28]=[CH:29][C:24]([NH:23][C:21](=[O:22])[NH:20][C:17]2[CH:18]=[CH:19][C:14]([N:9]3[CH:8]=[N:7][C:6]4[C:10]3=[N:11][CH:12]=[N:13][C:5]=4[C:3]([OH:4])=[O:2])=[CH:15][CH:16]=2)=[CH:25][C:26]=1[C:31]([F:34])([F:32])[F:33]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 59725881HCID 59725881, compound

Product 1

HCID 23154947HCID 23154947, compoundYield 69%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

In 3 mL of methanol, 45 mg (0.092 mmol) of 9-{4-[3-(4-chloro-3-(trifluoromethyl)phenyl)ureido]phenyl}-9H-purine-6-carboxylic acid methyl ester, and 2 mL of a 0.1 N sodium hydroxide aqueous solution was added thereto and the mixture solution was stirred at room temperature overnight. The reaction solution was neutralized with 0.1 N hydro-chloric acid, and then the deposited product was washed with water to obtain 30 mg (69%) of a target product as a pale yellow solid.

Workup

  1. washthe deposited product was washed with water

Sources & evidence

ORD record
ord-909a0d1e7480440f8d37df3bed67575d
Source dataset
uspto-grants-2013_12
Patent number
US08609656B2

Reaction notes

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