Hydrazine hydrate (1:1) → 4-(4-chloro-3-methylphenyl)-1H-pyrazole-3,5-diamine

Participants

Reaction Conditions

Reaction Steps

Hydrazine monohydrate (0.312 mL, 6.4 mmol) was added to a solution of the product from Example 47A (512 mg, 2.69 mmol) in CHCl3 (25 mL). The reaction flask was evacuated and purged with nitrogen (3 cycles) and the mixture was heated at 70° C. under nitrogen for 22 hours, then cooled to room temperature. The mixture was concentrated under vacuum to provide the title compound as a beige solid. MS (DCI/NH3) m/z 223/225 (M+H)+.

Provenance & Evidence