反应详情

温度

70 °C

Hydrazine monohydrate (0.312 mL, 6.4 mmol) was added to a solution of the product from Example 47A (512 mg, 2.69 mmol) in CHCl3 (25 mL). The reaction flask was evacuated and purged with nitrogen (3 cycles) and the mixture was heated at 70° C. under nitrogen for 22 hours, then cooled to room temperature. The mixture was concentrated under vacuum to provide the title compound as a beige solid. MS (DCI/NH3) m/z 223/225 (M+H)+.

1. customThe reaction flask was evacuated
2. custompurged with nitrogen (3 cycles)
3. temperaturecooled to room temperature
4. concentrationThe mixture was concentrated under vacuum