Hydrazine hydrate (1:1) → HCID 68753336, compound

HRID 1912907Notes

Reaction equation

HRID 1912907 reaction equation
[C:1]([CH:5]([C:8]#[N:9])[C:6]#[N:7])([CH3:4])([CH3:3])[CH3:2].O.[NH2:11][NH2:12]>C(O)CCC>[C:1]([C:5]1[C:8]([NH2:9])=[N:11][NH:12][C:6]=1[NH2:7])([CH3:4])([CH3:3])[CH3:2]

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 138154t-Butylmalononitrile

Product 1

HCID 68753336HCID 68753336, compoundYield 100.1%

Reagents, catalysts & solvents 1

HCID 2631-ButanolSolvent

Procedure

A mixture of tert-butylmalononitrile (5.01 g, 41.0 mmol) and hydrazine monohydrate (10.0 mL, 205 mmol) in 1-butanol (40 mL) was heated to reflux and stirred overnight (19 hours). The mixture was cooled to ambient temperature. Concentration afforded 6.33 g (100%) of the title compound. MS (DCI) m/z 155 (M+H)+.

Workup

  1. temperaturewas heated
  2. temperatureto reflux
  3. concentrationConcentration

Sources & evidence

ORD record
ord-75fbf83dcb7945799de9f764d2af89d9
Source dataset
uspto-grants-2013_12
Patent number
US08609669B2

Reaction notes

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