beta-Phenylisovaleric acid → 3-Methyl-3-phenylbutanoyl chloride

HRID 1912921Notes

Reaction equation

HRID 1912921 reaction equation
[CH3:1][C:2]([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)([CH3:7])[CH2:3][C:4](O)=[O:5].S(Cl)([Cl:16])=O>>[CH3:1][C:2]([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)([CH3:7])[CH2:3][C:4]([Cl:16])=[O:5]

Participants

3

Reactant 2

HCID 13890beta-Phenylisovaleric acidHCID 24386Thionyl Chloride

Product 1

HCID 128675683-Methyl-3-phenylbutanoyl chlorideYield 98.1%

Procedure

3-Methyl-3-phenylbutanoic acid (1.78 g, 10.0 mmol) was dissolved in thionyl chloride (5 mL, 68.5 mmol). The reaction mixture was heated at reflux for 6 hours. Concentration of the reaction mixture provided the title compound (1.93 g, 98%), which was used without additional purification.

Workup

  1. temperatureThe reaction mixture was heated
  2. temperatureat reflux for 6 hours

Sources & evidence

ORD record
ord-4a22026f9e2f450ab2a145771d43622f
Source dataset
uspto-grants-2013_12
Patent number
US08609669B2

Reaction notes

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