4-Fluorophenylacetyl chloride → HCID 68751712, compound

HRID 1912925Notes

Reaction equation

HRID 1912925 reaction equation
[C:1]([C:5]1[C:6]([NH2:14])=[N:7][N:8]2[CH:13]=[CH:12][CH:11]=[N:10][C:9]=12)([CH3:4])([CH3:3])[CH3:2].[F:15][C:16]1[CH:21]=[CH:20][C:19]([CH2:22][C:23](Cl)=[O:24])=[CH:18][CH:17]=1>>[C:1]([C:5]1[C:6]([NH:14][C:23](=[O:24])[CH2:22][C:19]2[CH:20]=[CH:21][C:16]([F:15])=[CH:17][CH:18]=2)=[N:7][N:8]2[CH:13]=[CH:12][CH:11]=[N:10][C:9]=12)([CH3:4])([CH3:2])[CH3:3]

Participants

3

Reactant 2

HCID 37449884-Fluorophenylacetyl chlorideHCID 687554713-Tert-butylpyrazolo[1,5-a]pyrimidin-2-amine

Product 1

HCID 68751712HCID 68751712, compound

Procedure

The product from Example 105B and 4-fluorophenylacetyl chloride were processed using the method analogous to that described in Example 105C to afford the title compound. 1H NMR (300 MHz, DMSO-d6) δ ppm 1.38 (s, 9H), 3.63 (s, 2H), 6.99 (dd, J=7.1, 4.1 Hz, 1H), 7.13-7.18 (m, 2H), 7.31-7.41 (m, 2H), 8.48 (dd, J=4.1, 1.7 Hz, 1H), 8.91 (dd, J=7.1, 1.7 Hz, 1H), 9.94 (s, 1H); MS (DCI) m/z 327 (M+H)+.

Sources & evidence

ORD record
ord-ae44a718a2de4fc283951ce8fb3c592f
Source dataset
uspto-grants-2013_12
Patent number
US08609669B2

Reaction notes

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