2-(3,5-Difluorophenyl)acetyl chloride → HCID 68749155, compound

HRID 1912929Notes

Reaction equation

HRID 1912929 reaction equation
[C:1]([C:5]1[C:6]([NH2:14])=[N:7][N:8]2[CH:13]=[CH:12][CH:11]=[N:10][C:9]=12)([CH3:4])([CH3:3])[CH3:2].[F:15][C:16]1[CH:17]=[C:18]([CH2:23][C:24](Cl)=[O:25])[CH:19]=[C:20]([F:22])[CH:21]=1>>[C:1]([C:5]1[C:6]([NH:14][C:24](=[O:25])[CH2:23][C:18]2[CH:17]=[C:16]([F:15])[CH:21]=[C:20]([F:22])[CH:19]=2)=[N:7][N:8]2[CH:13]=[CH:12][CH:11]=[N:10][C:9]=12)([CH3:4])([CH3:2])[CH3:3]

Participants

3

Reactant 2

HCID 27827232-(3,5-Difluorophenyl)acetyl chlorideHCID 687554713-Tert-butylpyrazolo[1,5-a]pyrimidin-2-amine

Product 1

HCID 68749155HCID 68749155, compound

Procedure

The product from Example 105B and 3,5-difluorophenylacetyl chloride were processed using the method analogous to that described in Example 105C to afford the title compound. 1H NMR (300 MHz, DMSO-d6) δ ppm 1.39 (s, 9H), 3.70 (s, 2H), 6.98-7.16 (m, 4H), 8.49 (dd, J=4.1, 1.7 Hz, 1H), 8.92 (dd, J=6.8, 1.7 Hz, 1H), 10.01 (s, 1H); MS (DCI) m/z 345 (M+H)+.

Sources & evidence

ORD record
ord-17444a69f2514dc499fc8917144007bd
Source dataset
uspto-grants-2013_12
Patent number
US08609669B2

Reaction notes

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