Cyclohexylacetyl chloride → HCID 68750173, compound

HRID 1912931Notes

Reaction equation

[C:1]([C:5]1[C:6]([NH2:14])=[N:7][N:8]2[CH:13]=[CH:12][CH:11]=[N:10][C:9]=12)([CH3:4])([CH3:3])[CH3:2].[CH:15]1([CH2:21][C:22](Cl)=[O:23])[CH2:20][CH2:19][CH2:18][CH2:17][CH2:16]1>>[C:1]([C:5]1[C:6]([NH:14][C:22](=[O:23])[CH2:21][CH:15]2[CH2:20][CH2:19][CH2:18][CH2:17][CH2:16]2)=[N:7][N:8]2[CH:13]=[CH:12][CH:11]=[N:10][C:9]=12)([CH3:4])([CH3:2])[CH3:3]

Participants

Reactant 2

HCID 2757989Cyclohexylacetyl chloride

HCID 687554713-Tert-butylpyrazolo[1,5-a]pyrimidin-2-amine

Product 1

HCID 68750173HCID 68750173, compound

Procedure

The product from Example 105B and 2-cyclohexylacetyl chloride were processed using the method analogous to that described in Example 105C to afford the title compound. 1H NMR (300 MHz, DMSO-d6) δ ppm 0.92-1.03 (m, 2H), 1.11-1.29 (m, 3H), 1.44 (s, 9H), 1.59-1.81 (m, 6H), 2.18 (d, J=6.1 Hz, 2H), 6.99 (dd, J=7.1, 4.1 Hz, 1H), 8.47 (dd, J=4.1, 1.7 Hz, 1H), 8.92 (dd, J=7.1, 1.7 Hz, 1H), 9.64 (s, 1H); MS (DCI) m/z 315 (M+H)+.

Sources & evidence

ORD record: ord-913c7119e8c94409a27ef1160ac9ade7
Source dataset: uspto-grants-2013_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08609669B2

Reaction notes

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