Cyclopentylacetyl chloride → HCID 68756285, compound

HRID 1912958Notes

Reaction equation

HRID 1912958 reaction equation
[C:1]([C:5]1[C:6]([NH2:14])=[N:7][N:8]2[CH:13]=[CH:12][CH:11]=[N:10][C:9]=12)([CH3:4])([CH3:3])[CH3:2].[CH:15]1([CH2:20][C:21](Cl)=[O:22])[CH2:19][CH2:18][CH2:17][CH2:16]1>>[C:1]([C:5]1[C:6]([NH:14][C:21](=[O:22])[CH2:20][CH:15]2[CH2:19][CH2:18][CH2:17][CH2:16]2)=[N:7][N:8]2[CH:13]=[CH:12][CH:11]=[N:10][C:9]=12)([CH3:4])([CH3:2])[CH3:3]

Participants

3

Reactant 2

HCID 3485182Cyclopentylacetyl chlorideHCID 687554713-Tert-butylpyrazolo[1,5-a]pyrimidin-2-amine

Product 1

HCID 68756285HCID 68756285, compound

Procedure

The product from Example 105B and cyclopentylacetyl chloride were processed using the method analogous to that described in Example 105C to afford the title compound. 1H NMR (300 MHz, DMSO-d6) δ ppm 1.13-1.24 (m, 2H), 1.45-1.65 (m, 13H), 1.71-1.82 (m, 2H), 2.19-2.28 (m, 3H), 6.99 (dd, J=7.1, 4.1 Hz, 1H), 8.48 (dd, J=3.9, 1.9 Hz, 1H), 8.92 (dd, J=7.0, 1.9 Hz, 1H), 9.64 (br s, 1H); MS (DCI) m/z 301 (M+H)+.

Sources & evidence

ORD record
ord-5bbf87468736473aad14453bb04ee92c
Source dataset
uspto-grants-2013_12
Patent number
US08609669B2

Reaction notes

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