4,4-Dimethylpentanoic acid → N-(3-tert-butylpyrazolo[1,5-a]pyrimidin-2-yl)-4,4-dimethylpentanamide

HRID 1912968Notes

Reaction equation

HRID 1912968 reaction equation
[C:1]([C:5]1[C:6]([NH2:14])=[N:7][N:8]2[CH:13]=[CH:12][CH:11]=[N:10][C:9]=12)([CH3:4])([CH3:3])[CH3:2].[CH3:15][C:16]([CH3:23])([CH3:22])[CH2:17][CH2:18][C:19](O)=[O:20]>>[C:1]([C:5]1[C:6]([NH:14][C:19](=[O:20])[CH2:18][CH2:17][C:16]([CH3:23])([CH3:22])[CH3:15])=[N:7][N:8]2[CH:13]=[CH:12][CH:11]=[N:10][C:9]=12)([CH3:4])([CH3:2])[CH3:3]

Participants

3

Reactant 2

HCID 142374,4-Dimethylpentanoic acidHCID 687554713-Tert-butylpyrazolo[1,5-a]pyrimidin-2-amine

Product 1

HCID 68754626N-(3-tert-butylpyrazolo[1,5-a]pyrimidin-2-yl)-4,4-dimethylpentanamide

Procedure

The product from Example 105B and 4,4-dimethylpentanoic acid were processed using the method analogous to that described in Example 137 to afford the title compound. 1H NMR (300 MHz, DMSO-d6) δ ppm 0.89 (s, 9H), 1.44 (s, 9H), 1.48-1.53 (m, 2H), 2.23-2.27 (m, 2H), 6.99 (dd, J=7.1, 4.0 Hz, 1H), 8.48 (dd, J=4.0, 2.0 Hz, 1H), 8.92 (dd, J=6.9, 1.8 Hz, 1H), 9.69 (s, 1H); MS (DCI) m/z 303 (M+H)+.

Sources & evidence

ORD record
ord-2bd52b83a3694bae9d1c0ef331377be0
Source dataset
uspto-grants-2013_12
Patent number
US08609669B2

Reaction notes

Loading…