(+/-)-ethyl 2-(1-methyl-2,3-dihydro-1H-inden-1-yl)acetate → ethyl 2-(2,3-dihydro-1H-inden-1-yl)acetate

HRID 1912970Notes

Reaction equation

HRID 1912970 reaction equation
C[C:2]1([CH2:11][C:12]([O:14][CH2:15][CH3:16])=[O:13])[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH2:4][CH2:3]1>CCO.[Pd]>[CH:2]1([CH2:11][C:12]([O:14][CH2:15][CH3:16])=[O:13])[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH2:4][CH2:3]1

Participants

4

Reactant 1

HCID 86665180(+/-)-ethyl 2-(1-methyl-2,3-dihydro-1H-inden-1-yl)acetate

Product 1

HCID 12322855ethyl 2-(2,3-dihydro-1H-inden-1-yl)acetateYield 100%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

To a mixture of products from Example 131A (0.47 g, 2.3 mmol) in EtOH (20 mL) was added Pd/C (49.5 mg, 0.046 mmol). The reaction mixture was stirred under H2 atmosphere using a balloon until the starting material completely consumed. The mixture was filtered and concentrated under reduced pressure to obtain 0.47 g of the title compound. MS (DCI/NH3) m/z 222 (M+NH4)+.

Workup

  1. customcompletely consumed
  2. filtrationThe mixture was filtered
  3. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-eed5562249a14ebfab76c882ef6eb241
Source dataset
uspto-grants-2013_12
Patent number
US08609669B2

Reaction notes

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