3,4-Dichlorophenylacetic acid → HCID 68753250, compound

HRID 1912979Notes

Reaction equation

HRID 1912979 reaction equation
[C:1]([C:5]1[C:6]([NH2:14])=[N:7][N:8]2[CH:13]=[CH:12][CH:11]=[N:10][C:9]=12)([CH3:4])([CH3:3])[CH3:2].[Cl:15][C:16]1[CH:17]=[C:18]([CH2:23][C:24](O)=[O:25])[CH:19]=[CH:20][C:21]=1[Cl:22]>>[C:1]([C:5]1[C:6]([NH:14][C:24](=[O:25])[CH2:23][C:18]2[CH:19]=[CH:20][C:21]([Cl:22])=[C:16]([Cl:15])[CH:17]=2)=[N:7][N:8]2[CH:13]=[CH:12][CH:11]=[N:10][C:9]=12)([CH3:4])([CH3:2])[CH3:3]

Participants

3

Reactant 2

HCID 798743,4-Dichlorophenylacetic acidHCID 687554713-Tert-butylpyrazolo[1,5-a]pyrimidin-2-amine

Product 1

HCID 68753250HCID 68753250, compound

Procedure

The product from Example 105B and 2-(3,4-dichlorophenyl)acetic acid were processed using the method analogous to that described in Example 137 to afford the title compound. 1H NMR (400 MHz, DMSO-d6/Deuterium Oxide) δ ppm 8.87 (d, J=5.9 Hz, 1H), 8.49 (dd, J=4.0, 1.8 Hz, 1H), 7.59-7.62 (m, 2H), 7.32-7.36 (m, 1H), 7.01 (dd, J=7.0, 4.0 Hz, 1H), 3.67-3.70 (bs, 2H), 1.39 (s, 9H); MS (ESI) m/z 377, 379 (M+H)+.

Sources & evidence

ORD record
ord-246a83210ed74835a76c37b9e5ecdbc9
Source dataset
uspto-grants-2013_12
Patent number
US08609669B2

Reaction notes

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