Tetrahydrofuran → (+/-)-Methyl 2-(4-(8-fluoro-1,2-dihydro-2-oxoquinazolin-3(4H)-yl)piperidine-1-carboxamido)-3-(7-methyl-1H-indazol-5-yl)propanoate

HRID 191299Notes

Reaction equation

HRID 191299 reaction equation
[C:18](=[O:19])([c:20]1[nH:21][cH:22][cH:23][n:24]1)[c:25]1[nH:26][cH:27][cH:28][n:29]1.[CH3:1][O:2][C:3]([CH:4]([CH2:5][c:6]1[cH:7][c:8]2[cH:9][n:10][nH:11][c:12]2[c:13]([CH3:15])[cH:14]1)[NH2:16])=[O:17].[F:30][c:31]1[cH:32][cH:33][cH:34][c:35]2[c:40]1[NH:39][C:38](=[O:41])[N:37]([CH:42]1[CH2:43][CH2:44][NH:45][CH2:46][CH2:47]1)[CH2:36]2.[O:48]1[CH2:49][CH2:50][CH2:51][CH2:52]1>>[CH3:1][O:2][C:3]([CH:4]([CH2:5][c:6]1[cH:7][c:8]2[cH:9][n:10][nH:11][c:12]2[c:13]([CH3:15])[cH:14]1)[NH:16][C:18](=[O:19])[N:45]1[CH2:44][CH2:43][CH:42]([N:37]2[CH2:36][c:35]3[cH:34][cH:33][cH:32][c:31]([F:30])[c:40]3[NH:39][C:38]2=[O:41])[CH2:47][CH2:46]1)=[O:17]

Participants

5

Reactant 4

HCID 8028TetrahydrofuranHCID 5250894Bis-(1H-imidazol-2-YL)-methanoneHCID 211022172(1h)-Quinazolinone,8-fluoro-3,4-dihydro-3-(4-piperidinyl)-HCID 58864334methyl 2-amino-3-(7-methyl-1H-indazol-5-yl)propanoate

Product 1

HCID 11454987(+/-)-Methyl 2-(4-(8-fluoro-1,2-dihydro-2-oxoquinazolin-3(4H)-yl)piperidine-1-carboxamido)-3-(7-methyl-1H-indazol-5-yl)propanoate

Sources & evidence

ORD record
ord-0cd22a8c6b244645a246327ae576d9f6
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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