Hydrochloric Acid → HCID 178490788, compound

HRID 1913129Notes

Reaction equation

HRID 1913129 reaction equation
[Cl:1][C:2]1[C:11]2[C:6](=[CH:7][C:8]([S:23](=[O:26])(=[O:25])[NH2:24])=[C:9]([O:12][C@@H:13]3[CH2:18][CH2:17][C@H:16]([NH:19]C(=O)C)[CH2:15][CH2:14]3)[CH:10]=2)[C:5](=[O:27])[N:4]([CH2:28][C:29]2[CH:34]=[CH:33][C:32]([O:35][CH3:36])=[CH:31][CH:30]=2)[CH:3]=1.Cl>C(O)C>[NH2:19][C@@H:16]1[CH2:15][CH2:14][C@H:13]([O:12][C:9]2[CH:10]=[C:11]3[C:6](=[CH:7][C:8]=2[S:23]([NH2:24])(=[O:26])=[O:25])[C:5](=[O:27])[N:4]([CH2:28][C:29]2[CH:30]=[CH:31][C:32]([O:35][CH3:36])=[CH:33][CH:34]=2)[CH:3]=[C:2]3[Cl:1])[CH2:18][CH2:17]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 178490789HCID 178490789, compound

Product 1

HCID 178490788HCID 178490788, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
90 °C

Procedure

32 mg of N-{4-[4-chloro-2-(4-methoxy-benzyl)-1-oxo-7-sulfamoyl-1,2-dihydro-isoquinolin-6-yloxy]-cis-cyclohexyl}-acetamide (130, crude product) were dissolved in 5 ml of ethanol and 15 ml of 2 N HCl and heated for 2 h at 90° C. The solvent was removed under reduced pressure and the residue was dissolved in 6 N HCl and heating at 90° C. was continued for 20 h. After cooling down to room temperature, the aqueous solution was evaporated and the title compound was isolated as HCl-salt (crude product). Rt=1.00 min (Method C). Detected mass: 492.5 (M+H+).

Workup

  1. customThe solvent was removed under reduced pressure
  2. dissolutionthe residue was dissolved in 6 N HCl
  3. temperatureAfter cooling down to room temperature
  4. customthe aqueous solution was evaporated

Sources & evidence

ORD record
ord-172742b6e3d44e699646a7bf4a767225
Source dataset
uspto-grants-2013_12
Patent number
US08609691B2

Reaction notes

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