2,2,2-Trifluoro-N-(4-hydroxycyclohexyl)-N-methylacetamide → HCID 178484843, compound

HRID 1913140Notes

Reaction equation

HRID 1913140 reaction equation
FC(F)(F)[C:3]([N:5]([CH:7]1[CH2:12][CH2:11][CH:10]([OH:13])[CH2:9][CH2:8]1)C)=O>Cl.O>[CH3:3][NH:5][C@H:7]1[CH2:12][CH2:11][C@H:10]([OH:13])[CH2:9][CH2:8]1

Participants

4

Reactant 1

HCID 584681842,2,2-Trifluoro-N-(4-hydroxycyclohexyl)-N-methylacetamide

Product 1

HCID 178484843HCID 178484843, compoundYield 126.4%

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidSolventHCID 962WaterSolvent

Procedure

2 g of 2,2,2-trifluoro-N-(4-hydroxy-cyclohexyl)-N-methyl-acetamide (149) were suspended in 10 mL of 1 N HCl and heated in a microwave at 150° until conversion was complete. The resulting solution was lyophilized and the residue was taken up in water and lyophilized again, twice to yield 1.45 g of 4-methylamino-cyclohexanol (150). Rt=0.13 min (Method C). Detected mass: 130.3 (M+H+).

Workup

  1. temperatureheated in a microwave at 150° until conversion

Sources & evidence

ORD record
ord-6f420c1b1401465dbdf2bf55004acb1a
Source dataset
uspto-grants-2013_12
Patent number
US08609691B2

Reaction notes

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