HuagongsheHuagongshe Chemistry Print Report · For research reference only
(1,1'-Biphenyl)-4-sulphonyl chloride → 2-[1-(biphenyl-4-ylsulfonyl)piperidin-4-yl]-1H-benzimidazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (1,1'-Biphenyl)-4-sulphonyl chloride | HCID 74192 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 2-(piperidin-4-yl)-1H-1,3-benzodiazole | HCID 715810 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 2-[1-(biphenyl-4-ylsulfonyl)piperidin-4-yl]-1H-benzimidazole | HCID 44565638 | 20.1% |
Reaction Steps
To a stirred mixture of 4-biphenylsulfonyl chloride (63 mg, 0.25 mmol) and 2-(piperidin-4-yl)-1H-benzimidazole (50 mg, 0.25 mmol) in DCM (10 mL) is added N,N-diisopropylethylamine (62 μL, 0.37 mmol). After 18 h the reaction mixture is washed with water and brine, dried over Na2SO4, filtered and concentrated under reduced pressure. Trituration with heptane gives 21 mg of 2-[1-(biphenyl-4-ylsulfonyl)piperidin-4-yl]-1H-benzimidazole.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08609696B2 |
| Source dataset | uspto-grants-2013_12 |
| ORD ID | ord-7ad410efecb945429ec478aaaf9a3ce8 |
| Source note | uspto-grants-2013_12 |