Hydrochloric Acid → [2,3'-Bipyridine]-6'-carboxylic acid dihydrochloride

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Reaction Steps

A stirred solution of methyl 2,3′-bipyridine-6′-carboxylate (0.103 g, 0.48 mmol) in 5M aqueous HCl (2.5 mL) is heated at 80° C. for 2 h. The reaction is concentrated under reduced pressure and azeotroped with MeOH to give crude 2,3′-bipyridine-6′-carboxylic acid dihydrochloride which is used in the next step without further purification. m/z=201 [M++H].

Provenance & Evidence