Hydrochloric Acid → [2,3'-Bipyridine]-6'-carboxylic acid dihydrochloride

HRID 1913155Notes

Reaction equation

HRID 1913155 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[C:7]1[CH:8]=[N:9][C:10]([C:13]([O:15]C)=[O:14])=[CH:11][CH:12]=1.[ClH:17]>>[ClH:17].[ClH:17].[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[C:7]1[CH:8]=[N:9][C:10]([C:13]([OH:15])=[O:14])=[CH:11][CH:12]=1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 58494565Methyl [2,3'-bipyridine]-6'-carboxylate

Product 1

HCID 66985091[2,3'-Bipyridine]-6'-carboxylic acid dihydrochloride

Procedure

A stirred solution of methyl 2,3′-bipyridine-6′-carboxylate (0.103 g, 0.48 mmol) in 5M aqueous HCl (2.5 mL) is heated at 80° C. for 2 h. The reaction is concentrated under reduced pressure and azeotroped with MeOH to give crude 2,3′-bipyridine-6′-carboxylic acid dihydrochloride which is used in the next step without further purification. m/z=201 [M++H].

Workup

  1. concentrationThe reaction is concentrated under reduced pressure
  2. customazeotroped with MeOH

Sources & evidence

ORD record
ord-2dc140f1b43046a8a66e0ddfaa3a12b2
Source dataset
uspto-grants-2013_12
Patent number
US08609696B2

Reaction notes

Loading…