Hydrazine hydrate (1:1) → 1-(6-Hydrazinopyridin-3-yl)-N-methylmethanamine

HRID 1913174Notes

Reaction equation

HRID 1913174 reaction equation
Cl[C:2]1[N:7]=[CH:6][C:5]([CH2:8][NH:9][CH3:10])=[CH:4][CH:3]=1.O.[NH2:12][NH2:13]>>[NH:12]([C:2]1[N:7]=[CH:6][C:5]([CH2:8][NH:9][CH3:10])=[CH:4][CH:3]=1)[NH2:13]

Participants

3

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 110948836-Chloro-N-methyl-3-pyridinemethanamine

Product 1

HCID 552791591-(6-Hydrazinopyridin-3-yl)-N-methylmethanamine

Procedure

1.0 g (6.4 mmol) of 1-(6-chloropyridin-3-yl)-N-methylmethanamine [for the preparation, see EP 0 556 684-A1] are initially charged in 1.5 ml (1.6 g, 31.9 mmol) of hydrazine hydrate and stirred at boiling point at a bath temperature of 150° C. for 12 h. The reaction solution is cooled and concentrated, and the residue is dried under reduced pressure. This gives 1.1 g of the title compound, which is used without any further purification.

Workup

  1. customtemperature of 150° C.
  2. customfor 12 h
  3. temperatureThe reaction solution is cooled
  4. concentrationconcentrated
  5. customthe residue is dried under reduced pressure
  6. customThis gives 1.1 g of the title compound, which is used without any further purification

Sources & evidence

ORD record
ord-86481ec87c4245cea16406c55c7329bf
Source dataset
uspto-grants-2013_12
Patent number
US08609698B2

Reaction notes

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