反应详情

2.2 g (14.0 mmol) of the compound from Example 12A are initially charged in 10 ml of ethanol. 7.0 g (140.0 mmol) of hydrazine hydrate are added, and the mixture is stirred under reflux for 16 h. The reaction mixture is then reacted again in a single-mode microwave oven (CEM Explorer) at 150° C. for 2 h. The mixture is then concentrated on a rotary evaporator, taken up in ethyl acetate, washed once with saturated sodium bicarbonate solution, dried over magnesium sulfate and concentrated again, and the residue is dried under high vacuum.

1. temperatureunder reflux for 16 h
2. customThe reaction mixture is then reacted again in a single-mode microwave oven (CEM Explorer) at 150° C. for 2 h
3. concentrationThe mixture is then concentrated on a rotary evaporator
4. washwashed once with saturated sodium bicarbonate solution
5. dry with materialdried over magnesium sulfate
6. concentrationconcentrated again
7. customthe residue is dried under high vacuum