Tert-Butylamine → HCID 68717765, compound

Participants

Reaction Steps

337 mg (1.0 mmol) of 6-(5-oxo-4-pyridin-3-yl-2,5-dihydro-1H-pyrazol-1-yl)pyridin-3-carbonyl chloride from Example 17 (Step a) are initially charged, a solution of 293 mg (4.0 mmol) of tert-butylamine in 15 ml of THF is added and the mixture is stirred at RT for 1 h. The mixture is then concentrated on a rotary evaporator, and the residue is purified by preparative HPLC (RP18 column; mobile phase: acetonitrile/water gradient with 0.1% TFA added to the water). The product-containing fractions are combined and concentrated. The residue is dissolved in 1 N hydrochloric acid, and the solution is then lyophilized.

Provenance & Evidence