反应详情

To a 250 mL round-bottom flask was charged ethyl 4-(2-tert-butoxy-2-oxoethylidene)cyclohexanecarboxylate (Int-4a, 5.38 g, 19.90 mmol) followed by EtOAc (100 mL). The flask was flushed with argon and then 5% palladium on carbon was added. The flask was sealed and degassed under vacuum. H2 (g) was added in a balloon and the reaction was allowed to stir 18 hours under hydrogen atmosphere. After 18 hours, the reaction mixture was filtered through celite. The solvent was removed in vacuo and the resulting oil was taken on without further purification.

1. customThe flask was flushed with argon
2. addition5% palladium on carbon was added
3. customThe flask was sealed
4. customdegassed under vacuum
5. additionH2 (g) was added in a balloon
6. waitAfter 18 hours
7. filtrationthe reaction mixture was filtered through celite
8. customThe solvent was removed in vacuo
9. customthe resulting oil was taken on without further purification