反应详情

To a 100 mL round-bottom flask was charged ethyl 4-(2-tert-butoxy-2-oxoethyl)cyclohexanecarboxylate (Int-4b, 2.00 g, 7.40 mmol) and 4N HCl in 1,4-dioxane. The resulting solution was stirred at room temperature for 2 hours. At this point the solvent was removed in vacuo and the resulting residue was diluted with DCM and washed with H2O. The organic layer was dried over Na2SO4 and reduced in vacuo. The resulting residue was taken on without further purification.

1. customAt this point the solvent was removed in vacuo
2. additionthe resulting residue was diluted with DCM
3. washwashed with H2O
4. dry with materialThe organic layer was dried over Na2SO4
5. customThe resulting residue was taken on without further purification