Hydrochloric Acid → HCID 69929788, compound

HRID 1913223Notes

Reaction equation

HRID 1913223 reaction equation
C[Si](C)(C)CCOC[N:7](COCC[Si](C)(C)C)[C:8]1[N:13]2[N:14]=[CH:15][C:16]([C:17]3[CH:18]=[N:19][C:20]([C:23]4[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=4)=[CH:21][CH:22]=3)=[C:12]2[N:11]=[C:10]([CH2:29][CH:30]2[CH2:35][CH2:34][CH:33]([C:36]([O:38][CH2:39][CH3:40])=[O:37])[CH2:32][CH2:31]2)[C:9]=1[C:41]([O:43]CC)=[CH2:42].Cl>CCO>[C:41]([C:9]1[C:10]([CH2:29][CH:30]2[CH2:35][CH2:34][CH:33]([C:36]([O:38][CH2:39][CH3:40])=[O:37])[CH2:32][CH2:31]2)=[N:11][C:12]2[N:13]([N:14]=[CH:15][C:16]=2[C:17]2[CH:18]=[N:19][C:20]([C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=3)=[CH:21][CH:22]=2)[C:8]=1[NH2:7])(=[O:43])[CH3:42]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 66896579HCID 66896579, compound

Product 1

HCID 69929788HCID 69929788, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a 20 mL scintillation vial containing ethyl 4-((7-(bis((2-(trimethylsilyl)ethoxy)methyl)amino)-6-(1-ethoxyvinyl)-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)methyl)cyclohexanecarboxylate (Int-4n, 113 mg, 0.144 mmol) was added EtOH (2 mL) followed by 4N HCl(aq). The resulting cloudy suspension was stirred at room temperature 1 hour, at which time the solution was now homogenous. The solvent was removed in vacuo and excess solvent was pumped off on high vacuum. The compound was taken on without further purification.

Workup

  1. customThe solvent was removed in vacuo and excess solvent
  2. customThe compound was taken on without further purification

Sources & evidence

ORD record
ord-839af1c7eff446e7a063da1412cfa179
Source dataset
uspto-grants-2013_12
Patent number
US08609675B2

Reaction notes

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