Ethyl 3-oxo-3-(1,4-dioxaspiro[4.5]decan-8-yl)propanoate → HCID 178515484, compound

HRID 1913227Notes

Reaction equation

HRID 1913227 reaction equation
O=[C:2]([CH:9]1[CH2:18][CH2:17][C:12]2([O:16][CH2:15][CH2:14][O:13]2)[CH2:11][CH2:10]1)[CH2:3][C:4]([O:6]CC)=O.[NH2:19][C:20]1[CH:24]=[CH:23][NH:22][N:21]=1>CCO>[O:13]1[C:12]2([CH2:11][CH2:10][CH:9]([C:2]3[CH:3]=[C:4]([OH:6])[N:21]4[N:22]=[CH:23][CH:24]=[C:20]4[N:19]=3)[CH2:18][CH2:17]2)[O:16][CH2:15][CH2:14]1

Participants

4

Reactant 2

HCID 66733231Ethyl 3-oxo-3-(1,4-dioxaspiro[4.5]decan-8-yl)propanoateHCID 178418806HCID 178418806, compound

Product 1

HCID 178515484HCID 178515484, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
100 °C

Procedure

To a 20 mL scintillation vial containing ethyl 3-oxo-3-(1,4-dioxaspiro[4.5]decan-8-yl)propanoate (Int-5d, 11.7 mmol, 3.00 g) was added 3-amino-1H-pyrazole (11.7 mmol, 973 mg). The mixture was mixed and heated neat at 100° C. for 3 hours. The resulting off-white solid was taken up in EtOH (100 mL) and reduced in vacuo to remove water formed during cyclization. This solid was taken forward without further purification.

Workup

  1. additionThe mixture was mixed
  2. customto remove water
  3. customformed during cyclization
  4. customThis solid was taken forward without further purification

Sources & evidence

ORD record
ord-0aa7901b78364218a7d604840122b8ef
Source dataset
uspto-grants-2013_12
Patent number
US08609675B2

Reaction notes

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