HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1913227Generated: November 2, 2026
Ethyl 3-oxo-3-(1,4-dioxaspiro[4.5]decan-8-yl)propanoate → HCID 178515484, compound
https://huagongshe.com/reaction/1913227
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ethyl 3-oxo-3-(1,4-dioxaspiro[4.5]decan-8-yl)propanoate | HCID 66733231 | — |
| Reactant | HCID 178418806 | HCID 178418806 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | HCID 178515484 | HCID 178515484 | — |
Reaction Steps
To a 20 mL scintillation vial containing ethyl 3-oxo-3-(1,4-dioxaspiro[4.5]decan-8-yl)propanoate (Int-5d, 11.7 mmol, 3.00 g) was added 3-amino-1H-pyrazole (11.7 mmol, 973 mg). The mixture was mixed and heated neat at 100° C. for 3 hours. The resulting off-white solid was taken up in EtOH (100 mL) and reduced in vacuo to remove water formed during cyclization. This solid was taken forward without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08609675B2 |
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| Source dataset | uspto-grants-2013_12 |
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| ORD ID | ord-0aa7901b78364218a7d604840122b8ef |
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| Source note | uspto-grants-2013_12 |
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