HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1913248Generated: November 1, 2026
tert-butyl 4-(7-(bis((2-(trimethylsilyl)ethoxy)methyl)amino)pyrazolo[1,5-a]pyrimidin-5-yl)-5,6-dihydropyridine-1(2H)-carboxylate → tert-Butyl 4-(7-(bis((2-(trimethylsilyl)ethoxy)methyl)amino)pyrazolo[1,5-a]pyrimidin-5-yl)piperidine-1-carboxylate
https://huagongshe.com/reaction/1913248
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | tert-butyl 4-(7-(bis((2-(trimethylsilyl)ethoxy)methyl)amino)pyrazolo[1,5-a]pyrimidin-5-yl)-5,6-dihydropyridine-1(2H)-carboxylate | HCID 66584699 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | tert-Butyl 4-(7-(bis((2-(trimethylsilyl)ethoxy)methyl)amino)pyrazolo[1,5-a]pyrimidin-5-yl)piperidine-1-carboxylate | HCID 66738492 | 100.6% |
Reaction Steps
A mixture of tert-butyl 4-(7-(bis((2-(trimethylsilyl)ethoxy)methyl)amino)pyrazolo[1,5-a]pyrimidin-5-yl)-5,6-dihydropyridine-1(2H)-carboxylate (Int-9e, 5.05 g) and 10% Pd/C (300 mg) in EtOAc was stirred at 45° C. under hydrogen (balloon pressure) for three hours. After filtration and concentration, tert-butyl 4-(7-(bis((2-(trimethylsilyl)ethoxy)methyl)amino)pyrazolo[1,5-a]pyrimidin-5-yl)piperidine-1-carboxy late (Int-9f) (5.1 g) was obtained as an oil. LC/MS: m/z=578.3 (M+H+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08609675B2 |
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| Source dataset | uspto-grants-2013_12 |
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| ORD ID | ord-0aa940016993440ca8c22a91896d2232 |
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| Source note | uspto-grants-2013_12 |
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