HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid water → Trifluoroacetic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid water | HCID 22392675 | — |
| Reactant | HCID 68089338 | HCID 68089338 | — |
| Product | Trifluoroacetic acid | HCID 6422 | — |
| Product | HCID 136332420 | HCID 136332420 | — |
Reaction Steps
(Z)-tert-butyl 4-(7-(bis((2-(trimethylsilyl)ethoxy)methyl)amino)-6-(2-ethoxyvinyl)-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)piperidine-1-carboxylate (Int-15a, 330 mg) was treated with TFA/water (1:1, 4 mL), stirred overnight, concentrated and lyophilized to provide the title compound as a TFA salt
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08609675B2 |
| Source dataset | uspto-grants-2013_12 |
| ORD ID | ord-20c233b1e47a436eaab6b5f7d93cc1eb |
| Source note | uspto-grants-2013_12 |