Trifluoroacetic acid water → Trifluoroacetic acid

HRID 1913264Notes

Reaction equation

HRID 1913264 reaction equation
C[Si](C)(C)CCOC[N:7]([CH2:47]OCC[Si](C)(C)C)[C:8]1[N:13]2[N:14]=[CH:15][C:16]([C:17]3[CH:18]=[N:19][C:20]([C:23]4[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=4)=[CH:21][CH:22]=3)=[C:12]2[N:11]=[C:10]([CH:29]2[CH2:34][CH2:33][N:32](C(OC(C)(C)C)=O)[CH2:31][CH2:30]2)[C:9]=1/[CH:42]=C\OCC.[C:57]([OH:63])([C:59]([F:62])([F:61])[F:60])=[O:58].O>>[C:23]1([C:20]2[N:19]=[CH:18][C:17]([C:16]3[CH:15]=[N:14][N:13]4[C:8]5[NH:7][CH:47]=[CH:42][C:9]=5[C:10]([CH:29]5[CH2:34][CH2:33][NH:32][CH2:31][CH2:30]5)=[N:11][C:12]=34)=[CH:22][CH:21]=2)[CH:24]=[CH:25][CH:26]=[CH:27][CH:28]=1.[C:57]([OH:63])([C:59]([F:62])([F:61])[F:60])=[O:58]

Participants

4

Reactant 2

HCID 22392675Trifluoroacetic acid waterHCID 68089338HCID 68089338, compound

Product 2

HCID 6422Trifluoroacetic acidHCID 136332420HCID 136332420, compound

Procedure

(Z)-tert-butyl 4-(7-(bis((2-(trimethylsilyl)ethoxy)methyl)amino)-6-(2-ethoxyvinyl)-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)piperidine-1-carboxylate (Int-15a, 330 mg) was treated with TFA/water (1:1, 4 mL), stirred overnight, concentrated and lyophilized to provide the title compound as a TFA salt

Workup

  1. concentrationconcentrated

Sources & evidence

ORD record
ord-20c233b1e47a436eaab6b5f7d93cc1eb
Source dataset
uspto-grants-2013_12
Patent number
US08609675B2

Reaction notes

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