Methanol → HCID 10801230, compound

HRID 1913423Notes

Reaction equation

HRID 1913423 reaction equation
[Br:1][C:2]1[CH:7]=[C:6]([O:8][CH3:9])[CH:5]=[CH:4][C:3]=1[CH2:10][C:11]([OH:13])=[O:12].[CH3:14]O>OS(O)(=O)=O>[CH3:14][O:12][C:11](=[O:13])[CH2:10][C:3]1[CH:4]=[CH:5][C:6]([O:8][CH3:9])=[CH:7][C:2]=1[Br:1]

Participants

4

Reactant 2

HCID 887MethanolHCID 39636682-Bromo-4-methoxyphenylacetic acid

Product 1

HCID 10801230HCID 10801230, compound

Reagents, catalysts & solvents 1

HCID 1118Sulfuric AcidCatalyst

Procedure

To a solution of (2-bromo-4-methoxy-phenyl)-acetic acid (1.07 g, 4.37 mmol) in 25 mL MeOH was added two drops of concentrated H2SO4 and the reaction was heated to reflux. After 18 hours, the solvent was removed in vacuo to give 920 mg of (2-bromo-4-methoxy-phenyl)-acetic acid methyl ester. This material was used directly in the next step without further purification.

Workup

  1. temperaturethe reaction was heated to reflux
  2. customthe solvent was removed in vacuo

Sources & evidence

ORD record
ord-08ca7c0ee84442aabfdc67bb4bf2f14c
Source dataset
uspto-grants-2013_12
Patent number
US08609680B2

Reaction notes

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