反应详情

温度

55 °C

To cyano-(4-methoxy-2-nitro-phenyl)-acetic acid ethyl ester (945 mg, 3.58 mmol) was added 30 mL of a saturated solution of aqueous sodium carbonate. The mixture was stirred overnight at 55° C. After cooling to room temperature, the mixture was diluted with ethyl acetate. The organic layer was washed with saturated brine, dried over Na2SO4 and concentrated in vacuo. The crude product was purified on a Biotage (Biotage Inc.) 10 g silica column, eluting with 0-40% EtOAc in heptanes to provide 258 mg (37%) of (4-methoxy-2-nitro-phenyl)-acetonitrile.

1. temperatureAfter cooling to room temperature
2. washThe organic layer was washed with saturated brine
3. dry with materialdried over Na2SO4
4. concentrationconcentrated in vacuo
5. customThe crude product was purified on a Biotage (Biotage Inc.) 10 g silica column
6. washeluting with 0-40% EtOAc in heptanes