Cesium carbonate → HCID 44125592, compound

HRID 1913506Notes

Reaction equation

HRID 1913506 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[S:9][CH:10]=[C:11]([CH2:13][S:14][C:15]3[N:20]=[C:19]([N:21]([CH3:27])[CH2:22][C:23]([O:25][CH3:26])=[O:24])[C:18]([C:28]#[N:29])=[C:17]([C:30]4[CH:35]=[CH:34][C:33]([O:36][CH2:37][CH2:38][OH:39])=[CH:32][CH:31]=4)[C:16]=3[C:40]#[N:41])[N:12]=2)=[CH:4][CH:3]=1.C(=O)([O-])[O-].[Cs+].[Cs+]>C(#N)C>[NH2:29][C:28]1[C:18]2[C:19](=[N:20][C:15]([S:14][CH2:13][C:11]3[N:12]=[C:8]([C:5]4[CH:4]=[CH:3][C:2]([Cl:1])=[CH:7][CH:6]=4)[S:9][CH:10]=3)=[C:16]([C:40]#[N:41])[C:17]=2[C:30]2[CH:31]=[CH:32][C:33]([O:36][CH2:37][CH2:38][OH:39])=[CH:34][CH:35]=2)[N:21]([CH3:27])[C:22]=1[C:23]([O:25][CH3:26])=[O:24]

Participants

4

Reactant 2

HCID 10796Cesium carbonateHCID 66671930HCID 66671930, compound

Product 1

HCID 44125592HCID 44125592, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Conditions

Temperature
50 °C

Procedure

21 mg (0.035 mmol) of the compound from Example 21A were initially charged in 0.69 ml of acetonitrile, and 45 mg (0.139 mmol) of cesium carbonate were added. The reaction mixture was stirred at 50° C. for 2 h and then cooled. The solid was filtered off and then washed with acetonitrile. The filtrate was concentrated and the residue was dried under high vacuum.

Workup

  1. temperaturecooled
  2. filtrationThe solid was filtered off
  3. washwashed with acetonitrile
  4. concentrationThe filtrate was concentrated
  5. customthe residue was dried under high vacuum

Sources & evidence

ORD record
ord-235f0e9498e94a2380db77deac065c7a
Source dataset
uspto-grants-2013_12
Patent number
US08609686B2

Reaction notes

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