Hexane → HCID 178479275, compound

HRID 1913530Notes

Reaction equation

HRID 1913530 reaction equation
C(OC(=O)[NH:7][C@H:8]1[CH2:13][CH2:12][C@H:11]([O:14][C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)[CH2:10][CH2:9]1)(C)(C)C.[ClH:22].C(OCC)(=O)C.CCCCCC>C(OCC)(=O)C>[ClH:22].[O:14]([C@H:11]1[CH2:10][CH2:9][C@H:8]([NH2:7])[CH2:13][CH2:12]1)[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1

Participants

5

Reactant 3

HCID 8058HexaneHCID 21866389Hydrogen chloride-ethyl acetateHCID 178454065HCID 178454065, compound

Product 1

HCID 178479275HCID 178479275, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

The compound (1.80 g) obtained in Step 1 of this Reference Example was dissolved in ethyl acetate (18.0 mL). To the solution, 4 M hydrochloric acid/ethyl acetate (18.0 mL) was added at room temperature, and the mixture was stirred for 1 hour. To the reaction solution, hexane (18.0 mL) was added, and the precipitated solid was then collected by filtration and washed with a mixed solvent of hexane and ethyl acetate (50:50) to obtain the title compound (1.01 g).

Workup

  1. filtrationthe precipitated solid was then collected by filtration
  2. washwashed with a mixed solvent of hexane and ethyl acetate (50:50)

Sources & evidence

ORD record
ord-ff85bacf5d7a41abbb8cbfb547b90e31
Source dataset
uspto-grants-2013_12
Patent number
US08609710B2

Reaction notes

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