Trifluoroacetic acid → (2E)-3-[5-(4-amidinophenoxycarbonyl)-thiophen-2-yl]-2-methylpropenoic acid trifluoroacetic acid salt

HRID 1913574Notes

Reaction equation

HRID 1913574 reaction equation
C([O:5][C:6](=[O:27])[C:7]([CH3:26])=[CH:8][C:9]1[S:10][C:11]([C:14]([O:16][C:17]2[CH:22]=[CH:21][C:20]([C:23](=[NH:25])[NH2:24])=[CH:19][CH:18]=2)=[O:15])=[CH:12][CH:13]=1)(C)(C)C.[F:28][C:29]([F:34])([F:33])[C:30]([OH:32])=[O:31]>>[F:28][C:29]([F:34])([F:33])[C:30]([OH:32])=[O:31].[C:23]([C:20]1[CH:21]=[CH:22][C:17]([O:16][C:14]([C:11]2[S:10][C:9](/[CH:8]=[C:7](\[CH3:26])/[C:6]([OH:27])=[O:5])=[CH:13][CH:12]=2)=[O:15])=[CH:18][CH:19]=1)(=[NH:24])[NH2:25]

Participants

3

Reactant 2

HCID 6422Trifluoroacetic acidHCID 866733173-[5-(4-Amidinophenoxycarbonyl)thiophen-2-yl]-2-methylpropenoic acid tert-butyl ester

Product 1

HCID 86673318(2E)-3-[5-(4-amidinophenoxycarbonyl)-thiophen-2-yl]-2-methylpropenoic acid trifluoroacetic acid salt

Procedure

To 3-[5-(4-amidinophenoxycarbonyl)thiophen-2-yl]-2-methylpropenoic acid tert-butyl ester (0.63 g) was added trifluoroacetic acid (5 mL), and the mixture was stirred for 30 minutes. The solvent was evaporated to give the title compound (0.62 g).

Workup

  1. customThe solvent was evaporated

Sources & evidence

ORD record
ord-61b7bce73538493aa2928ba643969830
Source dataset
uspto-grants-2013_12
Patent number
US08609715B2

Reaction notes

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