Trifluoroacetic acid → HCID 74982995, compound

HRID 1913575Notes

Reaction equation

HRID 1913575 reaction equation
[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].[C:8]([C:11]1[CH:37]=[CH:36][C:14]([O:15][C:16]([C:18]2[O:22][C:21]([CH2:23][CH2:24][C:25]([NH:27][C@H:28]([C:33]([OH:35])=[O:34])CC(O)=O)=[O:26])=[CH:20][CH:19]=2)=[O:17])=[C:13](OC)[CH:12]=1)(=[NH:10])[NH2:9].F[C:41](F)(F)[C:42]([OH:44])=[O:43]>>[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].[C:8]([C:11]1[CH:12]=[CH:13][C:14]([O:15][C:16]([C:18]2[O:22][C:21]([CH2:23][CH2:24][C:25]([N:27]([CH2:2][CH2:41][C:42]([OH:44])=[O:43])[CH2:28][C:33]([OH:35])=[O:34])=[O:26])=[CH:20][CH:19]=2)=[O:17])=[CH:36][CH:37]=1)(=[NH:10])[NH2:9]

Participants

3

Reactant 2

HCID 6422Trifluoroacetic acidHCID 86762185HCID 86762185, compound

Product 1

HCID 74982995HCID 74982995, compound

Procedure

To 5-(2-tert-butoxycarbonylethenyl)furan-2-carboxylic acid benzyl ester (0.15 g, 0.46 mmol) obtained in Example 41, step 2 was added trifluoroacetic acid (3 ml), and the mixture was stirred for 30 minutes. The solvent was evaporated under reduced pressure to give the title compound.

Workup

  1. customThe solvent was evaporated under reduced pressure

Sources & evidence

ORD record
ord-b2d74fff304c42ea818d2282e6c55891
Source dataset
uspto-grants-2013_12
Patent number
US08609715B2

Reaction notes

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