反应详情

温度

120 °C

A mixture of 1.41 g of 2-(3-fluoropyridin-4-yl)-5-(trifluoromethyl)benzoxazole, 1.85 g of phthalimide potassium and 8 ml of DMF was stirred while heating at 120° C. After six hours, 0.92 g of phthalimide potassium was added and stirred while heating at 140° C. for further one hour. The reaction mixture was cooled to room temperature, and then water was added to the reaction mixture, which followed by extraction with ethyl acetate twice. The combined organic layers were washed with water and a saturated sodium chloride solution, sequentially, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure. The residue was subjected to silica gel column chromatography to give 1.26 g of N-{4-[5-(trifluoromethyl)benzoxazole-2-yl]pyridin-3-yl}phthalimide.

1. stirringstirred
2. temperaturewhile heating at 140° C. for further one hour
3. temperatureThe reaction mixture was cooled to room temperature
4. extractionfollowed by extraction with ethyl acetate twice
5. washThe combined organic layers were washed with water
6. dry with materiala saturated sodium chloride solution, sequentially, dried over anhydrous magnesium sulfate
7. concentrationconcentrated under reduced pressure