HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → Methyl 4-{(3E)-2-[2-(4-cyanophenyl)ethyl]-4-[2-(4,4,4-trifluorobutoxy)phenyl]but-3-en-1-yl}benzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 4-Bromo-1,1,1-trifluorobutane | HCID 521006 | — |
| Reactant | Methyl E-4-[2-[2-(4-cyanophenyl)ethyl]-4-(2-hydroxyphenyl)but-3-enyl]benzoate | HCID 57831366 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | Methyl 4-{(3E)-2-[2-(4-cyanophenyl)ethyl]-4-[2-(4,4,4-trifluorobutoxy)phenyl]but-3-en-1-yl}benzoate | HCID 59180507 | — |
Reaction Steps
A solution of 200 mg (0.486 mmol) of methyl 4-[(3E)-2-[2-(4-cyanophenyl)ethyl]-4-(2-hydroxyphenyl)but-3-en-1-yl]benzoate in 5 ml of acetonitrile is mixed with 101 mg (0.73 mmol) of potassium carbonate and 139 mg (0.73 mmol) of 4,4,4-trifluoro-1-bromobutane and stirred under reflux for 12 h. After conversion is complete, the salts are filtered off and the mother liquor evaporated. 253 mg (0.49 mmol, 100% of theory) of the title compound are obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08609727B2 |
| Source dataset | uspto-grants-2013_12 |
| ORD ID | ord-f9fd400c54964a07b23675f77220170e |
| Source note | uspto-grants-2013_12 |