反应详情

A solution of 200 mg (0.486 mmol) of methyl 4-[(3E)-2-[2-(4-cyanophenyl)ethyl]-4-(2-hydroxyphenyl)but-3-en-1-yl]benzoate in 5 ml of acetonitrile is mixed with 101 mg (0.73 mmol) of potassium carbonate and 139 mg (0.73 mmol) of 4,4,4-trifluoro-1-bromobutane and stirred under reflux for 12 h. After conversion is complete, the salts are filtered off and the mother liquor evaporated. 253 mg (0.49 mmol, 100% of theory) of the title compound are obtained.

1. temperatureunder reflux for 12 h
2. filtrationthe salts are filtered off
3. customthe mother liquor evaporated