HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Fluoro-2-(hydroxymethyl)phenol → (5-Fluoro-2-hydroxybenzyl)(triphenyl)phosphonium bromide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Fluoro-2-(hydroxymethyl)phenol | HCID 10606838 | — |
| Reactant | Triphenylphosphonium hydrobromide | HCID 22178555 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | (5-Fluoro-2-hydroxybenzyl)(triphenyl)phosphonium bromide | HCID 86638793 | — |
Reaction Steps
18.6 g (130.87 mmol) of 4-fluoro-2-(hydroxymethyl)phenol and 42.67 g (124.32 mmol) of triphenylphosphonium hydrobromide are stirred under reflux in 186 ml of acetonitrile for 3 h. After cooling, the resulting precipitate is filtered off with suction and dried. 58 g (124 mmol, 100% of theory) of the title compound are obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08609727B2 |
| Source dataset | uspto-grants-2013_12 |
| ORD ID | ord-6a6d73db6cc44345937be5b7bc49ab27 |
| Source note | uspto-grants-2013_12 |