反应详情

A solution of 392 mg (0.72 mmol) of methyl 4-[(4E)-5-[2-(4-bromobutoxy)phenyl]-3-(4-cyanobenzyl)pent-4-en-1-yl]benzoate in 10 ml of dry acetonitrile is mixed with 120 mg (1.08 mmol) of 4-fluorophenol and 148 mg (1.08 mmol) of anhydrous potassium carbonate and then heated under reflux for 12 h. The mixture is subsequently filtered, and the filtrate is evaporated to dryness. 445 mg (0.71 mmol, purity 93%, 99% of theory) of a yellowish oil are isolated.

1. temperatureheated
2. temperatureunder reflux for 12 h
3. filtrationThe mixture is subsequently filtered
4. customthe filtrate is evaporated to dryness
5. custom445 mg (0.71 mmol, purity 93%, 99% of theory) of a yellowish oil are isolated