Aluminium lithium hydride → HCID 66663807, compound

HRID 1913810Notes

Reaction equation

HRID 1913810 reaction equation
C(O[C:6](=O)[NH:7][C@H:8]1[CH2:17][CH2:16][C:15]2[C:10](=[CH:11][CH:12]=[C:13]([C:18]([N:20]3[CH2:24][CH2:23][CH2:22][CH2:21]3)=O)[CH:14]=2)[CH2:9]1)(C)(C)C.[H-].[Al+3].[Li+].[H-].[H-].[H-]>>[CH3:6][NH:7][C@H:8]1[CH2:17][CH2:16][C:15]2[C:10](=[CH:11][CH:12]=[C:13]([CH2:18][N:20]3[CH2:24][CH2:23][CH2:22][CH2:21]3)[CH:14]=2)[CH2:9]1

Participants

3

Reactant 2

HCID 21226445Aluminium lithium hydrideHCID 66663930[(S)-6-(pyrrolidine-1-carbonyl)-1,2,3,4-tetrahydronaphthalen-2-yl]carbamic acid tert-butyl ester

Product 1

HCID 66663807HCID 66663807, compound

Procedure

According to method B, [(S)-6-(pyrrolidine-1-carbonyl)-1,2,3,4-tetrahydro-naphthalen-2-yl]carbamic acid tert-butyl ester was reacted with lithium aluminum hydride (10 equiv., 60° C., 2 hours). The product was thus obtained with the molecular weight of 244.38 (C16H24N2); MS (ESI): 245 (M+H+).

Workup

  1. customThe product was thus obtained with the molecular weight of 244.38 (C16H24N2)

Sources & evidence

ORD record
ord-db07546646794763b1e09e3b1776b9ac
Source dataset
uspto-grants-2013_12
Patent number
US08609731B2

Reaction notes

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