反应详情

温度

150 °C

A mixture of N-((S)-6-bromo-1,2,3,4-tetrahydronaphthalen-2-yl)-4-methoxybenzamide (3.0 g), glacial acetic acid (2 ml) and HBr (20 ml; 48% in water) was heated to 150° C. in a closed glass vessel in a microwave reactor for 25 minutes. The precipitate obtained after the cooling was filtered off. The product was thus obtained with the molecular weight of 346.23 (C17H16BrNO2); MS (ESI): 346 (M+H+). Both N-((S)-6-bromo-1,2,3,4-tetrahydronaphthalen-2-yl)-4-methoxybenzamide and N-((R)-6-bromo-1,2,3,4-tetrahydronaphthalen-2-yl)-4-methoxybenzamide were obtained by literature methods (J. Org. Chem. 1995, 60, 4324).

1. customThe precipitate obtained after the cooling
2. filtrationwas filtered off
3. customThe product was thus obtained with the molecular weight of 346.23 (C17H16BrNO2)