反应详情

A mixture of N-((S)-6-allyl-1,2,3,4-tetrahydronaphthalen-2-yl)-4-[(S)-1-(tetrahydrofuran-2-yl)methoxy]benzamide (0.50 g), 2-propanol (50 ml) and water (50 ml) was admixed with sodium periodate (0.60 g) and osmium tetroxide (1.3 mg). After stirring vigorously for 14 hours, the reaction mixture was extracted with ethyl acetate. The organic phase was washed with sodium chloride solution, dried over sodium sulfate and concentrated. The product was thus obtained with the molecular weight of 393.49 (C24H27NO4); MS (ESI): 394 (M+H+).

1. extractionthe reaction mixture was extracted with ethyl acetate
2. washThe organic phase was washed with sodium chloride solution
3. dry with materialdried over sodium sulfate
4. concentrationconcentrated
5. customThe product was thus obtained with the molecular weight of 393.49 (C24H27NO4)