反应详情

温度

50 °C

A mixture of 6-chloroadenosine (1 g, 3.5 mmol) and hydrazine monohydrate (5 mL) in MeOH (10 mL) was stirred at 50° C. for 1 hr. The reaction mixture was allowed to cool to room temperature and was then concentrated in vacuo to provide a crude residue which was suspended in MeOH and (10 mL) and stirred at room temperature. The solid product that separated out from the suspension was filtered, washed with MeOH and dried in vacuo to provide N6-hydrazinoadenosine (970 mg) which was used without further purification.

1. temperatureto cool to room temperature
2. concentrationwas then concentrated in vacuo
3. customto provide a crude residue which
4. stirring(10 mL) and stirred at room temperature
5. customThe solid product that separated out from the suspension
6. filtrationwas filtered
7. washwashed with MeOH
8. customdried in vacuo