反应详情

温度

80 °C

To a solution of tert-butyl 5-[6-{3-[(2R)-2-methylpyrrolidin-1-yl]propoxy}-2-oxo-3,4-dihydroquinolin-1(2H)-yl]-1H-indole-1-carboxylate (Compound No. 41) prepared in the same manner as shown in Example 1 (0.050 g) in methanol (0.19 mL), water (0.3 mL) and potassium carbonate (0.041 g) were added and stirred at 80° C. for 2 hours. The reaction mixture was concentrated under reduced pressure, and the resulting residue was purified by NH-type preparative TLC (on three plates of 0.25 mm thickness, developing solvent: ethyl acetate) to give the titled compound (0.0090 g, 2.2%) as a colorless amorphous substance.

1. additionwere added
2. concentrationThe reaction mixture was concentrated under reduced pressure
3. customthe resulting residue was purified by NH-type preparative TLC (on three plates of 0.25 mm thickness, developing solvent: ethyl acetate)