反应详情

Sorafenib free base (2 g) was added to a saturated solution of p-toluenesulphonic acid (22.0 g) in water (10 mL). The reaction mixture was stirred at about 30° C. to about 32° C. for about 12 hours. The reaction mixture was filtered. The solid material was washed with acetone (2×10 mL) and dried under reduced pressure at about 50° C. for about 12 hours to obtain sorafenib tosylate.

1. filtrationThe reaction mixture was filtered
2. washThe solid material was washed with acetone (2×10 mL)
3. customdried under reduced pressure at about 50° C. for about 12 hours