Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
3-Chloropyridine-4-carboxylic acid → 2-[1-(3-Chloroisonicotinoyl)piperidin-4-yl]-5-(3,4-dimethoxyphenyl)-4,4-dimethyl-2,4-dihydro-3H-pyrazol-3-one
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 3-Chloropyridine-4-carboxylic acid | HCID 2735816 | — |
| 반응물 | 5-(3,4-dimethoxyphenyl)-4,4-dimethyl-2-piperidin-4-yl-2,4-dihydro-3H-pyrazol-3-one hydrochloride | HCID 66616406 | — |
| 생성물 | 2-[1-(3-Chloroisonicotinoyl)piperidin-4-yl]-5-(3,4-dimethoxyphenyl)-4,4-dimethyl-2,4-dihydro-3H-pyrazol-3-one | HCID 46204651 | — |
반응 단계
The title compound is prepared analogously as described for GP2-WU2 using 5-(3,4-dimethoxyphenyl)-4,4-dimethyl-2-(piperidin-4-yl)-2,4-dihydro-3H-pyrazol-3-one (compound B1) and 3-chloroisonicotinic acid as starting compounds. The crude product is purified by chromatography (silica gel and DCM/diethyl ether/methanol=10:10:1) to yield the title compound.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08609848B2 |
| 출처 데이터셋 | uspto-grants-2013_12 |
| ORD ID | ord-cf092674037947ceae4dfbdabf3ce1ec |
| 출처 메모 | uspto-grants-2013_12 |