Hydrochloric Acid → 5-(3,4-Dimethoxyphenyl)-4,4-dimethyl-2-piperidin-4-yl-2,4-dihydro-3H-pyrazol-3-one

HRID 1914220Notes

Reaction equation

HRID 1914220 reaction equation
Cl.Cl.[CH3:3][O:4][C:5]1[CH:6]=[C:7]([C:13]2[C:14]([CH3:26])([CH3:25])[C:15](=[O:24])[N:16]([CH:18]3[CH2:23][CH2:22][NH:21][CH2:20][CH2:19]3)[N:17]=2)[CH:8]=[CH:9][C:10]=1[O:11][CH3:12].[OH-].[Na+]>O>[CH3:3][O:4][C:5]1[CH:6]=[C:7]([C:13]2[C:14]([CH3:26])([CH3:25])[C:15](=[O:24])[N:16]([CH:18]3[CH2:23][CH2:22][NH:21][CH2:20][CH2:19]3)[N:17]=2)[CH:8]=[CH:9][C:10]=1[O:11][CH3:12]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 666164065-(3,4-dimethoxyphenyl)-4,4-dimethyl-2-piperidin-4-yl-2,4-dihydro-3H-pyrazol-3-one hydrochloride2×

Product 1

HCID 666164075-(3,4-Dimethoxyphenyl)-4,4-dimethyl-2-piperidin-4-yl-2,4-dihydro-3H-pyrazol-3-one

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

The hydrochloride of the title compound (compound B1*HCl) is suspended in water, and the aqueous layer is basified with 5 M aqueous sodium hydroxide solution to a pH above 10. The aqueous phase is extracted three times with DCM, dried over MgSO4 and concentrated in vacuo resulting in the title compound. (compound B1)

Workup

  1. extractionThe aqueous phase is extracted three times with DCM
  2. dry with materialdried over MgSO4
  3. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-6ebf418b39e5471ca61ae93626ef6bd5
Source dataset
uspto-grants-2013_12
Patent number
US08609848B2

Reaction notes

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